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(中科院)恶性肿瘤冷冻消融和介入治疗前后肿瘤标志物变化研究_2010.11.1

热度:★★★★★   日期:2014-6-25    来源:互联网

 

项目来源:中国科学院再生生物学重点实验室

课题名称:恶性肿瘤冷冻消融和介入治疗前后肿瘤标志物变化研究

申请者:邱大卫

所在单位:广州复大肿瘤医院

申请时间:2010年11月1日

 

研究内容和预期成果:

The presence of serum tumor markers, carbohydrate antigen 242 (CA242), carbohydrate antigen 199 (CA199), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), tumorsupplied group of factors (TSGF) and tumor necrosis factor-a (TNF-a), is closely associated with invasion and metastasis of many malignancies. The expression of these markers were measured in serum taken from 37 pancreatic cancer patients prior to treatment. Levels of CA242, CA199, CA125, CEA and TNF-a expression correlated with tumor size, clinical stage, tumor differentiation, lymph node and liver metastasis (P\0.05). One month after cryosurgery, serum levels of these markers were significantly reduced compared with levels prior to cryosurgery (P\0.05), whereas there was no significant difference was found between serum levels before and after chemotherapy (P[0.05). Thus, cryosurgery is more effective than chemotherapy for decreasing CA242, CA199, CA125, CEA, TSGF and TNF-a serum levels in these patients.


 
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