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陈继冰 医学博士

热度:★★★★★   日期:2014-6-20   来源:互联网

 

专长和成就 (临床专业知识)

2011年9月赴美国休斯顿的MD Anderson肿瘤中心参观学习;2011年10月赴奥地利维也纳参加世界冷冻协会第16届年会,大会发言获优秀论文奖;国际上首次提出“冷冻-细胞免疫疗法”治疗中晚期肿瘤,2013年应邀赴马来西亚、印尼、印度等国进行学术交流,“冷冻-细胞免疫疗法”获得国内外同行的广泛认可与好评。目前正与美国密歇根大学联合开展肿瘤干细胞疫苗相关研究。

评价亚健康状体以及免疫功能低下,首先需要借助科学的数据检测来界定免疫功能低下真实存在。淋巴细胞亚群计数是目前公认的最具科学性的免疫细胞数量的检测方法,而血浆细胞因子测定是最权威的免疫细胞功能的检测方法。我院开展这两种检测的临床研究已有3年的历史,借助国际公认的检测仪器和试剂套装已为陈伟添、恩当、郭林等2000余名国内外肿瘤患者提供检测服务以及治疗指导,具有丰富的临床经验,其检测和治疗的严谨性、科学性、安全性以及有效性广受国内外肿瘤患者的好评,经多项院内研究证实免疫治疗的显著有效率可达90%以上。

医生名称(职称): 

陈继冰 医学博士 

中心实验室 首席专家

科室主任

个人介绍或者行医经验或者心得体会:

“免疫治疗是公认为癌症第四大疗法,我2007年毕业于吉林大学医学院免疫学专业,现为国际冷冻学会会员, 肿瘤免疫治疗专家。 已从事临床免疫治疗及研究7年,擅长肿瘤患者免疫功检测及多种免疫治疗方法。提高病人的免疫功能,有效地延长患者的生命,是我义不容辞的职责。”

 

熟悉的语言:中文、英文

Email:jibingchen398@163.com

我的团队:

生物治疗中心

主治过的病人(典型病例)或曾参与过治疗的特殊病例

1, Giglia的故事 胃癌-澳大利亚

2, Rus的故事  肾癌骨转移-菲律宾

3, Wata 的故事 胰腺内分泌肿瘤(WDHA 综合征)-菲律宾/英国

4, 穆德. 阿里(Meddy Ali)的故事 鼻咽癌-印尼

5, 陈小悦的故事 腹腔脂肪肉瘤-北京

6, 恩当(EndangRahayuSedyaningsih)部长的故事 非小细胞性肺癌-印尼

7, 郭林的故事 胰腺癌伴肝转移-丹麦

8, 胡万正的故事 原发性肝癌-深圳

9, 丽拉的故事 软骨细胞成骨肉瘤-丹麦

10, 王倩倩的故事 心包血管肉瘤-北京

11, 张秀美淋巴瘤的故事 淋巴瘤-印尼

12, 赵先生的故事 肝癌-台湾

13, 陈伟添的故事 胰腺癌-马来西亚

 

主要著作和论文

至2013年共参与国家、省市级基金资助研究12项,以第一或通讯作者发表“冷冻-细胞免疫疗法”相关SCI论文51篇。

1.Chen J (第一作者), Yang W, Yu C, Li Y. Autoimmune regulator initiates the expression of promiscuous genes in thymic epithelial cells. Immunol Invest. 2008;37(3):203-14. 

2.Chen X, Shao W, Chen J (第三作者), Corbascio M, Qi Z. Allotransplantati on of sulphate glucomannan-alginate barium (SGA)-microencapsulated rat islets for the treatment of diabetes mellitus. Immunol Invest. 2009;38(7): 561-71. 

3.Xie B, Chen J (联合第一作者), Xia J, Wang Y, Liang H, Ekberg H, Corbascio M, Qi Z. Combined costimulation blockade inhibites accelerated rejection mediated by alloantigen primed memory T cells in micel. Immunol Invest. 2009;38(7): 639-51. 

4.Liang H, Liao C, Qi Z, Sha C, Xie B, Chen J (第六作者), Xia J, Wang Y, Yao Q, Zhao Y. Rapamycin or tacrolimus alone fails to resist cardiac allograft accelerated rejection mediated by alloreactive CD4(+) memory T cells in mice.Transpl Immunol.2010; 22(3-4): 128-36.

5.Wang Y, Qin Q, Chen J (联合第一作者), Kuang X, Xia J, Xie B, Wang F, Liang H, Qi Z. Synergistic effects of Isatis tinctoria L. and tacrolimus in the prevention of acute heart rejection in mice. Transpl Immunol. 2009; 22(1-2): 5-11. 

6.Zhao Y, Zhang S, Zhou J, Wang J, Zhen M, Liu Y, Chen J (第七作者), Qi Z. The development of a tissue-engineered artery using decellularized scaffold and autologous ovine mesenchymal stem cells. Biomaterials. 2010;31(2): 296-307. 

7.Liang H, Zhao Y, Shan Z, Liao C, Sha C, Xie B, Chen J (第六作者), Xia J, Wang Y, Qi Z. The recall alloresponse following retransplantation is more intense compared with the T cell memory-transfer model.Immunol Invest. 2010; 39(1): 39-53.

8.Xie B, Chen J (联合第一作者), Wang F, Lan T, Wang Y, Xia J, Li Z, Xie Q, Huang R, Qi Z. Monoclonal antibody treatment to prolong the secondary cardiac allograft survival in alloantigen-primed mice. Scand J Immunol, 2010;71(5):345-52.

9.Kang X, Chen J (联合第一作者), Qin Q, Wang F, Wang Y, Lan T, Xu S, Wang F, Xia J, Ekberg H, Qi Z, Liu Z.Isatis tinctoria L. combined with co-stimulatory molecules blockade prolongs survival of cardiac allografts in alloantigen-primed mice. Transpl Immunol. 2010; 23 (1-2): 34-9. 

10.Lan T, Chen J (联合第一作者), Xia J, Wang Y, Xie B, Wang F, Qi Z. Inhibition of alloantigen-primed memory CD4+ and CD8+ T cells by hematopoietic chimerism in mice. Scand J Immunol. 2010; 72(2): 86-93. 

11.Su Z, Xia J, Shao W, Cui Y, Tai S, Ekberg H, Corbascio M, Chen J (联合通讯作者), Qi Z. Small islets are essential for successful intraportal transplantation in a diabetes mouse model. Scand J Immunol. 2010; 72(6): 504-10. 

12.Xu S, Chen J (联合第一作者), Wang F, Kang X, Lan T, Wang F, Li Z, Qi Z. Arsenic trioxide combined with co-stimulatory molecule blockade prolongs survival of cardiac allografts in alloantigen-primed mice. Transpl immunol. 2010; 24(1): 57-63. 

13.Shao W, Chen J (联合第一作者), Wang F, Xia J, Qi Z. Combined application of blocking antibodies and microRNA interference in inhibiting CD44 Expression. Transpl P. 2010; 42(7): 2777–81. 

14.Wang F, Chen J (联合第一作者), Shao W, Xie B, Wang Y, Lan T, Thorlacius H, Qi Z. Anti-CD44 Monoclonal Antibody Inhibits Heart Transplant Rejection Mediated by Alloantigen-primed CD4+Tm in Nude Mice. Immunol Invest. 2010; 39(8): 807-10. 

15.Xia J, Chen J (第二作者), Shao W, Lan T, Wang Y, Xie B, Thorlacius H, Tian F, Huang R, Qi Z. Suppressing memory T cell activation induces islet allograft tolerance in alloantigen-primed mice. Transpl Int. 2010; 23(11):1154-63. 

16.Chen J (第一作者), Xia J, Axelsson B, Fritzson I, Ekberg H, Törngren M, Qi Z, Xing J. An N-(alkylcarbonyl)anthranilic acid derivative prolongs cardiac allograft survival synergistically with cyclosporine A in a high-responder rat model. Transpl immunol. 2010, 23(4): 180-4. 

17.Huang Y, Wang Y, Chen J (联合第一作者), Wang F, Kang X, Xia J, Lan T, Xie B, Ekberg H, Wang X, Qi Z. Prevention of acute and chronic allograft rejection by combinations of tolerogenic dendritic cells. Scand J Immunol. 2010; 73(2): 91-101. 

18.Wang F, Xia J, Chen J (联合第一作者), Peng Y, Cheng P, Ekberg H, Wang X, Qi Z. Combination of antibodies inhibits accelerated rejection mediated by memory T cells in xenoantigen-primed mice. Xenotransplantation. 2010; 17(6): 460-8. 

19.Wang F, Chen J (联合第一作者), Shao W, Kang X, Xu S, Xia J, Dai H, Peng Y, Thorlacius H, Xing J, Qi Z. The major histocompatibility complex (MHC) of the secondary transplant tissue donor influences the cross-reactivity of alloreactive memory cells. Scand J Immunol. 2011; 73(3): 190-7. 

20.Cheng P, Xia J, Wang H, Chen J(第4作者), Wang F, Zhang Y, Huang X, Zhang Q, Qi Z. Islet transplantation reverses the effects of maternal diabetes on mouse oocytes. Reproduction. 2011; 141(4): 417-24. 

21.Dai H, Chen J (联合第一作者), Shao W, Wang F, Xu S, Peng Y, Lin Y, Xia J, Ekberg H, Wang X, Qi Z. Blockade of CD27/CD70 pathway to reduce the generation of memory T cells and markedly prolong the survival of heart allografts in presensitized mice. Transpl Immunol. 2011; 24(4): 195-202. 

22.Shao W, Chen J (联合第一作者), Dai H, Peng Y, Wang F, Xia J, Thorlacius H, Zhu Q, Qi Z. Combination of monoclonal antibodies with DST inhibits accelerated rejection mediated by memory T cells to induce long-lived heart allograft acceptance in mice. Immunol Lett. 2011; 138(2): 122-8. 

23.Peng Y, Chen J (联合第一作者), Shao W, Wang F, Dai H, Cheng P, Xia J, Wang F, Huang R, Zhu Q, Qi Z. Xenoreactive CD4(+) memory T cells resist inhibition by anti-CD44 mAb and reject islet grafts via a Th2-dependent pathway. Xenotransplantation. 2011; 18(4): 252-61.

24.Lin Y, Dai H, Su J, Yan G, Xi Y, Ekberg H, Chen J (联合通讯作者), Qi Z. Arsenic trioxide is a novel agent for combination therapy to prolong heart allograft survival in allo-primed T cells transferred mice.Transpl Immunol. 2011;25(4):194-201.

25.Niu L, Li J, Chen J (联合第一作者), Zhou L, Wu B, Zeng J, Fang G, Deng C, Yao F, Chen Z, Leng Y, Deng M, Deng C, Zhang B, Liao M, Xu K, Zuo J, Xu K. Comparison of dual- and triple-freeze protocols for pulmonary cryoablation in a Tibet pig model.Cryobiology. 2012; 64(3): 245-9. 

26.Li J, Chen J (联合第一作者), Zhou L, Zeng J, Yao F, Wu B, Fang G, Deng C, Chen Z, Leng Y, Xu K, Niu L, Zuo J, Xu K. Comparison of dual- and triple-freeze protocols for hepatic cryoablation in a Tibet pig model. Cryobiology. 2012; 65(1):68-71.

27.Li J, Zhou L, Chen J (联合第一作者), Wu B, Zeng J, Fang G, Deng C, Huang S, Yao F, Chen Z, Leng Y, Deng M, Deng C, Zhang B, Zhou G, He L, Liao M, Chiu D, Niu L, Zuo J, Xu K. Pancreatic Head Cryosurgery: Safety and Efficiency In Vivo-A Pilot Study. Pancreas. 2012; 41(8): 1285-91.

28.Chen J (联合第一作者), Liang B, Yuan Y, Liu C, Li L, Li H, Mu F, Zuo J, Xu K. Comprehensive treatment of malignant mesothelioma patients after the failure of systemic chemotherapy. Cryobiology. 2012; 65(3): 284-8. 

29.Yan G, Xi Y, Xu S, Chen J (第三作者), Lin Y, Dai H, Cheng P, Xiao H, Liu Z, Qi Z. Inhibiting accelerated rejection mediated by alloreactive CD4(+) memory T cells and prolonging allograft survival by 1α,25-dihydroxyvitamin D(3) in nude mice. Immunol Lett. 2012; 149(1-2):54-6.

30.Chen J(联合第一作者), Li J, He L, Liu W, Yao F, Zeng J, Zhang Y, Xu K, Niu L, Zuo J, Xu K. Radical treatment of stage IV pancreatic cancer by the combination of cryosurgery and iodine-125 seed implantation. World J Gastroenterol. 2012; 18 (47): 7056-62. 

31.Mu F, Niu L, Li H, Liao M, Li L, Liu C, Chen J (联合通讯作者), Li J, Zuo J, Xu K. Percutaneous comprehensive cryoablation for metastatic hepatocellular cancer. Cryobiology. 2013; 66(1): 76-80. 

32.Niu L, Wang Y, Yao F, Wei C, Chen Y, Zhang L, Chen J (联合通讯作者), Li J, Zuo J, Xu K. Alleviating visceral cancer pain in patients with pancreatic cancer using cryoablation and celiac plexus block. Cryobiology. 2013; 66(2): 105-11. 

33.Mu F, Liu SP, Zhou XL, Chen J(联合通讯作者), Li HB, Zuo JS, Xu KC. Prevention of needle-tract seeding by two-step freezing after lung cancer biopsy. Pathol Oncol Res. 2013; 19(3):447-50. 

34.Li J, Zhang C, Chen J(联合通讯作者), Yao F, Zeng J, Huang L, Yang X, Liu W, Chen F, Xu K, Yang D, Niu L, Zuo J, Xu K, Liu D.Two case reports of pilot percutaneous cryosurgery in familial multiple endocrine neoplasia type 1. Pancreas. 2013;42(2):353-7.

35.Niu L, Mu F, Zhang C, Li Y, Liu W, Jiang F, Li L, Liu C, Zeng J, Yao F, Chen J (联合通讯作者), Li J, Zuo J, Xu K. Cryotherapy protocols for metastatic breast cancer after failure of radical surgery. Cryobiology. 2013;67(1):17-22.

36.Niu L,Li J,Zeng J,Mu F, Liao M, Yao F, Li L, Liu C, Chen J (联合通讯作者), Zuo J, Xu K. Combination treatment with comprehensive cryoablation and immunotherapy in metastatic hepatocellular cancer. World J Gastroenterol. 2013;19(22): 3473-80.

37.Zhang S, Chen Z, Yang R, Chen J (第二作者), Cheng P, He Z, Liu Z, Qi Z. Irinotecan combined with co-stimulatory molecule blockade prolongs survival of cardiac allografts in alloantigen-primed mice. Cell Immunol. 2013; 282(2): 85-92.

38.Yan G, Xi Y, Xu S, Lin Y, Chen J (第三作者) , Dai H, Xia J, Li C, Li Q, Li Z, Qi Z. Inhibition of accelerated rejection mediated by alloreactive CD4(+) memory T cells and prolonged allograft survival by arsenic trioxide. Immunol Invest. 2013;42(5):438-54.

39.Niu L, Chen J (联合第一作者), Yao F, Zhou L, Zhang C, Wen W, Bi X, Hu Y, Piao X, Jiang F, Zeng J, Liu W, Li J, He L, Mu F, Zuo J, Xu K. Percutaneous cryoablation for stage IV lung cancer: a retrospective analysis. Cryobiology. 2013; 67(2): 151-5.

40.Shi J, Niu L, Huang Z, Mu F, Chen J(联合通讯作者), Li J, Xu K. Diagnosis and treatment of coagulopathy following percutaneous cryoablation of liver tumors: Experience in 372 patients. Cryobiology. 2013; 67(2): 146-50. 

41.Zhang Z, Wu B, Niu L, Mu F, Chen J(联合通讯作者), Li J, Zuo J, Xu K. Combination percutaneous cryotherapy and iodine-125 seed implantation for unresectable malignant thymoma: Experience in 19 patients. Cryobiology. 2013; 67(2): 170-4.

42.Niu L, Chen J (联合第一作者), He L, Liao M, Yuan Y, Zeng J, Li J, Zuo J, Xu K. Combination treatment with comprehensive cryoablation and immunotherapy in metastatic pancreatic cancer. Pancreas. 2013; 42(7):1143-9.

43.Zhang Z, Niu L, Zhou L, Zeng J, Yao F, Chen J(联合通讯作者), Li J, Xu K.  Treatment of central type lung cancer by combined cryotherapy: Experiences of 47 patients. Cryobiology. 2013; 67(2): 225-9.

44.Yuan Y, Niu L, Mu F, Wang X, Zeng J, Yao F, Jiang F, He L, Chen J(联合通讯作者), Li J, Xu K. Therapeutic outcomes of combining cryotherapy, chemotherapy and DC-CIK immunotherapy in the treatment of metastatic non-small cell lung cancer. Cryobiology. 2013; 67(2): 235-40.

45.Li J, Chen F, Xu Z, Chen J (第4作者), Lv X, Zhang L, Liu D. Transcription-replication collision increases recombination efficiency between plasmids. Plasmid. 2013; 70(3): 406-11.

46.Zhou L, Yao Fei, Niu L, Zeng J, Zhang Z, Chen J (联合通讯作者), Li J, Xu K. Percutaneous cryotherapy for metastatic bladder cancer: Experience with 23 patients. Cryobiology. 2013;68(1):79-83.

47.Xu J, Niu L, Mu F, Liu S, Leng Y, Liao M, Zeng J, Y F, Chen J (联合通讯作者), Li J, Xu K. Percutaneous comprehensive cryoablation for metastatic esophageal cancer after failure of radical surgery. Cryobiology. 2013;67(3):363-8.

48.Long X, Zeng J, Niu L, Y Fei, Wang X, Chen J (联合通讯作者), Li J, Xu K. Alleviating the pain of unresectable hepatic tumors by percutaneous cryoablation: experience in 73 patients. Cryobiology. 2013;67(3):369-73.

49.Li H, Tang K, Niu L, Liang Y, Li J, Chen J(联合通讯作者), Xu K. Carcinoembryonic antigen as prognostic factor for metastatic non-small cell lung cancer by percutaneous cryosurgery. Cancer Biomark. 2013;13(5):337-43.

50.Niu L, Li J, Zeng J, Zhou L, Wang S, Zhou X, Sheng L, Chen J(联合通讯作者), Xu K.Comparison of percutaneous cryoablation with microwave ablation in a porcine liver model.Cryobiology. 2014

51.Xu J, Li J, Zhou X, Zeng J, Yao F, Wang Y, Mu F, Niu L, Chen J(联合通讯作者), Liu J, Xu K.Cryotherapy for local recurrent dermatofibrosarcoma protuberans: Experience in 19 patients.Cryobiology. 2014;68(1):134-8.

 

媒体报道与相关视频

1. 2013年9月2日马来西亚《光明日报》报道:

 

陈继冰 医学博士 相关的视频:

 


3D视频:联合免疫疗法(CIC)

陈继冰 医学博士 相关的图片集:

 

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陈继冰 医学博士
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